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This research provides additional evidence to suggest that discontinuing GLP-1 agonists at least 14 days before total joint replacement surgery is optimal to reduce the risk of delayed emergence from anesthesia, aspiration events, aspiration pneumonitis ,and conversion to intubation, said study author John R
The phase 2 trial showed 17.1% average body weight reduction at 48 weeks with the 4mg dose
Importantly, the weight-reducing efficacy appears comparable to that observed in common, polygenic obesity, as preliminarily evidenced by subgroup analyses from large trials such as SURMOUNT-1